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Conclusions:
There were differentially expressed genes related with angiogenesis between normal and diabetic keratocytes of OLETF. Especially, Integrin alpha 1 gene expressed up-regulated in diabetes treated with IL-1à, and Angiotensin II type I receptor gene showed up-regulated in stimulated with TNF-à. Studies to analyze the apoptotic significance of the identified differences of diabetes are needed.
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