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Results:
Diabetes showed down-regulated 20 genes and up-regulated 14 genes compared with normal keratocytes. IL-1à treated diabetic keratocyte expressed 20 down-regulated and 16 up-regulated genes. Compared with diabetic keratocytes, the up-regulated expressed genes in OLETF treated with TNF-à were as Angiotensin II type-I receptor, Integrin alpha 1, Dimethylarginine dimethylaminohydrolase 1, Pituitary tumor transforming 1. Tenomodulin. Real-time PCR showed a significant increase in the IL-6, Integrin alpha 1, and Angiotensin II type I receptor gene.
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