Poster # P-155 WITHDRAWN - Effect of Bevacizumab on Rabbit Corneal Neovascularization and Human Microvascular Endothelial Cells

Presenter: Lee, Ji-Eun

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Bevacizumab (2.5mg/0.1cc) was administered to four rabbits' eyes by subconjunctival injection immediately after chemical burn was made on rabbit cornea with silver nitrate soaking Whatman filter paper. As a control, four eyes received an injection of balanced salt solution (0.1cc). Three and eight days later, the inhibition of coneal NV was evaluated with biomicrogaphy, fluorescein angiography, and histologic examination. HUVEC cells were with 10 ng/ml of vascular endothelial growth factor (VEGF) and 0.125 mg/ml, 0.25 mg/ml, 0.5 mg/ml, 1 mg/ml and 2 mg/ml of either bevacizumab for 2, 6, and 24 hours. The effect on VEGF-induced HUVEC proliferation, migration, and tube formation was examined.

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